• fiat_lux@kbin.social
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    6 months ago

    Hm, 5 year old journal, with the editor board, funding and half of the authors all from the Chinese Academy of Sciences, but significant hospital contribution. I remain skeptical of the headline but hopeful of the science.

  • hOrni@lemmy.world
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    6 months ago

    And it will be provided for free to anyone who needs it, right? Right?

    • Sibbo@sopuli.xyz
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      5 months ago

      True. How could it be a free market if corporations are not allowed to form a cartel and agree on a price for a product that is literally vital for many people?

  • Sam_Bass@lemmy.ml
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    5 months ago

    ‘Further studies are needed for validation.’ Understatement of the year

    • some_guy@lemmy.sdf.org
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      5 months ago

      I’m hopeful but wary. Medical science keeps being the one thing left in this world that consistently makes me happy to be alive in modern times. This would be a great breakthrough.

          • HumanPenguin@feddit.uk
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            6 months ago

            Not OP but thanks for sharing a good link.

            Technically it is not a cure for type 2. But a repair to further damage caused by a life of type 2.

            The type 2 diabetic is still insulin resistant after this treatment. It is just some of the harm that resistance dose to their islet cells. Makeing them partly mimic type 1 diabetes with reduced insulin production. Can be rebuilt with stem cells.

            The patient will still need to eat and manage carbs as a well treated type 2 must. To avoid having issues.

      • greentreerainfire@kbin.social
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        6 months ago

        As a lay-person, it seems kind of light on details and a bit fanciful. The article states they created pancreatic islet seed cells, but fails to link how exactly this cures diabetes. (I’m assuming these cells create the insulin.)

        Another point is this seems to fly in t he face of what we’ve been told for decades, that diabetes can now be cured and not just managed. (I personally don’t have a problem with this, everything is impossible until it becomes possible.)

        The biggest issue I see is that this cured one person. Diabetes is a fairly common condition, they shouldn’t have had a problem getting more participants in a study.

        • rando895@lemmygrad.ml
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          6 months ago

          I believe that it states somewhere that it was a case study or a proof of concept. Which is a common approach to interventions (medical or otherwise) that are difficult, expensive, and time consuming. If you can find a way to get it to work then maybe it’s worth expanding and finding more efficient/effective ways of implementing the intervention.

        • Schadrach@lemmy.sdf.org
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          5 months ago

          Islet cells are the insulin secreting cells in the pancreas. This literally sounds like the general idea is that if you don’t have sufficient insulin production to cover the load your body is under, solving it by engineering new islet cells from your own tissues (so as to avoid rejection) and then implanting them.

          Basically, if your pancreas isn’t strong enough to do the job, then just add more pancreas until it is.

  • DarthYoshiBoy@kbin.social
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    5 months ago

    So this is neat. Potentially life changing for some type 2 diabetics, but that depends because some t2 diabetics are not failing to make enough insulin, they’re just no longer sensitive to it at a level that makes it functional for them. I suppose it’s possible that this therapy could cause them to grow enough islet β cells to overcome their lack of sensitivity, but (and I’m a type 1, not a type 2, so maybe my info is incorrect here) that lack of sensitivity can grow with further exposure to insulin making this a stop-gap at best for those cases absent other therapies.

    …and with all of that said, being able to regrow islet β cells has never really been the problem for type 1 diabetes. You can regrow all the islet β cells you’d like and it’s not going to cure the underlying immune disease that has caused your immune system to kill off all of your islet β cells to begin with. Unless you can figure out why t1 diabetes causes one’s own immune system to go psycho killer on their islet β cells, you’ve done nothing to “cure” diabetes. Without being able to suppress that impulse for your immune system to murder your own cells, any ability to replace the islet β cells is going to be temporary at best, and probably a waste on the whole.

    My brother in law is a “cured” type 1 diabetic, by virtue of his having had a kidney replacement and being on immune suppressing drugs for that. Since they were already replacing the kidney and he was going to have to take immune system suppression medications for that, they also just replaced his pancreas at the same time and the suppression of his immune system has allowed the new pancreas to thrive and continue to make insulin. Easy-peasy. The only trade-off is that he is super immunocompromised and can be killed by common colds, so not a great strategy in general.

  • SeattleRain@lemmy.world
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    5 months ago

    Why is everyone online so incredulous of this breakthrough? Is it just Sinophobia or are there reasons to doubt Chinese medical findings?

    • ILikeBoobies@lemmy.ca
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      5 months ago

      There’s reason to doubt all sensationalist medical headlines

      But this is 1 patient, no long term effects studied (just doesn’t need insulin injections), and hasn’t been validated

      Nothing to do with China

    • Raiderkev@lemmy.world
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      5 months ago

      Their Covid vaxx was trash. My aunt’s friend was a UAE resident, and got sinovac Covid shot. He later caught and died from covid, so that’s my anecdotal reason not to trust it, but if it is true, this would be a great thing.

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          5 months ago

          You’re an idiot if you can’t read a whole 2 sentences and grasp any sort of reading comprehension.

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    5 months ago

    It’s sad to see USA so shackled by pure capitalism that it starts to lose its scientific edge left and right while drooling libs jerk off to the big pharma freedom of unrestrained gains. Still believing they have a chance for a piece from the cake if only they squeeze their cheeks a little harder.

    • KredeSeraf@lemmy.world
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      5 months ago

      I am super confused by your take here. Liberals who, and let’s be clear, regularly push for better if not universal health care (and are the only major party to do so) jerk off big Pharma to you? How exactly do you get to that conclusion?

      • 𝓔𝓶𝓶𝓲𝓮@lemm.ee
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        5 months ago

        Liberals means different things around the world. Here it means free markets circlejerkers, Adam smith cultists, invisible hand of the market preachers while at the same time anti lgbt for some reason. Pro freedom but anti freedom. Full of paradoxes. Neonazi too and even conservative despite based around free market peddling.

        After all we live in a post truth word where even people who agree with each other cannot communicate anymore due to shifting meaning of the words thanks to the politicians and media.

        How can we even converse if the words itself are stolen, changed and used for war? Do we need to use mathematics instead of language if the latter is disfigured beyond recognition? Changed into a tool of some demagogue?

        • sneakybells@lemmy.ml
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          5 months ago

          Adam Smith had a completely different definition of “free markets” than Neoliberals did.

        • UmeU@lemmy.world
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          5 months ago

          You just said that liberals are hardcore capitalists despite the fact that liberals are the ones pushing for a hybrid socialist democracy where key industries are socialized so that rampant corruption, which is an effect of the invisible hand, can be avoided. You go on to say that liberal means conservative.

          Phrases like ‘we are living in a post truth world’ are a self fulfilling prophecy for those who use that phrase… for the rest of us you just sound like a far-right provocateur.

          It appears you are either very confused or you are a dishonest interlocutor and are completely full of shit.

            • UmeU@lemmy.world
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              5 months ago

              This is a really insightful argument you have proposed. am going to have to give it a lot of thought because it’s so sophisticated and well thought out/communicated. You should be proud of yourself.

          • sparkle@lemm.ee
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            5 months ago

            “Liberal” isn’t only a word used for modern US/Canadian progressives. “Liberal” is used to mean someone who believes in “free-market” capitalism, free trade, private ownership of the means of production and anti-nationalizationism, anti-protectionism/anti-regulationism, and individualism/anti-collectivism. It’s pretty much synonymous with right-wing “libertarian” ideologies, including neoliberalism, classical liberalism, and "anarcho"capitalism. This is what the word has always referred to normally, and is by far the most common usage in most of the world, and it’s still used this way in the US – mainly in economic, philisophical, or “fundamental rights” contexts though.

            Liberalism is pretty much the antithesis of socialism, in a purely left-versus-right sense at least. The American ideology is often considered “social liberalism” or even “modern American liberalism”, which still holds beliefs of individualism and capitalism, but differs from liberalism in that it pushes for a regulated mixed economy, as well as the government contributing to fulfilling social needs like healthcare, education, and infrastructure. It also is defined by focusing on social justice/civil rights, as opposed to traditional liberalism (which is opposed to social justice and civil rights, believing people in a “free market” will decide to do the right thing). It ranges from being a centrist ideology to being a left-leaning right-wing ideology, so when the only opposition is basically dormant fascism, it is the “left” ideology. In a full political view though, it isn’t leftism.

            The American misappropriation of the term came from a time when the word “progressive” was starting to be seen as “radical” (and therefore negative). Progressives started using “liberal” instead, and it became a way to say “I only want some government intervention in the economy and social issues, but not a radical amount”. When New Deal politicians like FDR popularized it, it kind of became cemented in American political discourse as meaning that.

            • UmeU@lemmy.world
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              5 months ago

              Modern American liberalism is democratic socialism and that’s what it has meant since FDR…

              "In the United States, liberalism is associated with the welfare-state policies of the New Deal programme of the Democratic administration of Pres. Franklin D. Roosevelt, whereas in Europe it is more commonly associated with a commitment to limited governmentand laissez-faire economic policies."Consequently, the ideas of individualism and laissez-faire economics previously associated with classical liberalism are key components of modern American conservatism and movement conservatism, and became the basis for the emerging school of modern American libertarian thought.

              This doesn’t mean that liberalism = conservatism.

              • sparkle@lemm.ee
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                5 months ago

                Surely you must notice that “Modern American Liberalism” and “Liberalism” are two separate terms? “Liberal” can mean MANY things other than American liberalism. It even specifies in the article you’re quoting. You cannot just assume that any and every usage of the term “liberal” is in reference to social liberalism, even in America it’s still used in the common/typical/“original” sense frequently (just not by uninformed voters).

                And AFAIK nobody said anything about liberalism (and American liberalism) and conservativism being equivalent either. “Conservative” is a significantly more broad term than “liberal” and it’s impossible to definitively equate or oppose them, but generally conservativism is opposite to progressivism – seeing how liberalism is usually socially progressive, it isn’t generally a perfect match. But there does exist “conservative liberalism”, which is socially conservative and economically liberal – in theory what American conservatives are supposed to be, but in reality they’re a bit more… fascist.

                Relatively though, American liberals are significantly more conservative than, say, socialists and most leftist ideologies. They still hold many very (especially fiscally) conservative beliefs. There are plenty of American liberals that are in the pockets of big pharma.

                Also calling modern American liberalism “socialism”, even “democratic socialism”, is laughable. Socialism requires abolishing capitalism and having the means of production belong to the workers/public. Democratic socialism is an ideology that believes that socialism can be achieved through peaceful democratic reform rather than violent revolution. Modern American liberalism specifically advocates for a mixed economy with mostly private, but some nationalized, industries, which is very much NOT socialist. It is quite literally, regulated capitalism. It also specifies that in the same article you quoted. You can’t just take any welfare state (or attempt at one) and call it socialism.

                For the most part, “lib” is synonymous with “so-called market capitalist and liberty advocate”, i.e. almost all Americans in politics. A non-American using it to describe American politicians bought out by big pharma makes perfect sense, as most of them also claim to like the free market and (negative) freedom and stuff.

              • 𝓔𝓶𝓶𝓲𝓮@lemm.ee
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                5 months ago

                Damn I am trying to stay classy today despite all odds. I may need to kill someone (in a game) before the day comes to an end to release that steam from hormone inbalances

                Fuck it I am going out

      • Glytch@lemmy.world
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        5 months ago

        Liberals don’t do that, progressives do. Liberals say that universal health care is too complicated and nuanced so we better just stick with the system we have because that’s generating profits so it must be working.

      • Buddahriffic@lemmy.world
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        5 months ago

        They might mean neo libs.

        It’s fucking annoying when capitalists keep coming up with capitalist positions and naming them so that they sound like they are something else. Like neo liberalism or libertarianism, which are pretty close to the same thing (all about a deregulated, private, free market), only libertarians like to emphasize how they are ok with sex and drugs.

        Liberals want governments and collective public elements to protect the rights and freedoms of individuals (from other individuals, organizations, and governments).

        Neo liberals want governments and collective public elements to stay out of their affairs and let them manage their own interests.

        • alcoholicorn@lemmy.ml
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          5 months ago

          Liberals want governments and collective public elements to protect the rights and freedoms of individuals (from other individuals, organizations, and governments).

          If the overarching “freedoms of individuals” is the freedom to exploit the labor of individuals then yes, that’s the core of liberalism.

          If by “collective public elements” you meant collectivizing the means of production, then no, that’s socialism/anarchism/other.

          • Buddahriffic@lemmy.world
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            5 months ago

            That’s the core of neo liberalism. Liberalism has a “my rights end where yours begin” component but neo liberalism drops that and expects the free market to solve such conflicts.

            And by “collective public elements”, I meant public organizations like the postal service, police departments, etc. The government itself is supposed to be one of those. Liberalism is neutral on what is and isn’t collectivized. Neo liberalism likes privatization but appreciates that some functions are better handled by the public, like law enforcement and road maintenance. Libertarianism believes it should all be private.

            In the last comment I said neo liberalism and libertarianism are pretty much the same, but it’s more accurate to say libertarianism is an extreme version of neo liberalism.

            • alcoholicorn@lemmy.ml
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              5 months ago

              Liberalism has a “my rights end where yours begin”

              No, it’s always been the defense of exploitation when it comes into conflict with any other supposed right.

              Here’s one of my favorite books, it goes through the history and evolution of Liberalism: http://acdc2007.free.fr/losurdo2011.pdf

              It’s special because most liberal thought is taught as something that was born, fully formed, from the minds of men in the 1700s, and exists entirely divorced from context and material conditions.

    • shameless@lemmy.world
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      5 months ago

      I mean it is… They could literally have a cure that they can sell to millions of people around the world, as well as millions more who will contract diabetes in the future.

      I don’t understand this conspiracy and companies don’t want cures. I can understand scepticism around pharmaceutical companies for all the awful shit they’ve done, but it doesn’t mean that scientists and researchers will never be able to produce cures.

      • matcha_addict@lemy.lol
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        5 months ago

        Pharma investors have a solid position and are already racking big profits from the continuous model of insulin treatments. A cure would be a detriment to their profits, so it’s not something they’re interested in funding.

        No investor nowadays thinks a one-time-payment product is worthwhile. We’re already way past that.

        This isn’t to mention that if you were an investor who decided you wanted to go ahainst that, that the other mega corporations (with more funds than most of those 5% individuals) wouldn’t engage in anti competitive practices to shut you down. Many companies had good products but still ultimately failed. I mean hell, the boeing events have shown us the lengths a corporation is willing to go to protect its profits, and that’s just what we heard of.

        Unfortunately capitalism does not allow innovation to flourish like many of us were taught to believe.

      • Asafum@feddit.nl
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        5 months ago

        I don’t exactly subscribe to the conspiracy but I can understand it as it’s related to “planned obsolescence.” Companies don’t want to sell you a quality product that will last “forever” they want to sell you something that’s just good enough to work for a bit, but will absolutely break or be replaced very soon so you become a repeat customer as opposed to a one time customer.

        The same logic applies here with the medication, why would they sell something once even if there were new future customers, if they could instead have everyone on a “subscription” of sorts?

        The conspiracy exists because we see it play out in every other facet of our society/economy. Everything is becoming a subscription, you don’t own anything, every product a corporation makes is almost complete garbage, etc… I’m not sure I believe it 100% but I wouldn’t in the slightest bit be surprised to find out that actually was the case.

        • pingveno@lemmy.ml
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          5 months ago

          There is no grand secret conspiracy. Why? The more people involved in a conspiracy, the more likely it will leak out. A conspiracy between two people may never get it, a conspiracy between a hundred people will have someone slip up in a few years at most, but an international conspiracy involving millions of people with disparate interests wouldn’t stay secret for a second.

          What we’re seeing isn’t a conspiracy as such. It’s a conversation happening in the open about “business models” and “revenue streams”. It’s also based on customer expectations. There are definitely markets out there for the repairable, buy it for life goods, but there’s just not nearly as big as the customer who upgrades their phone every two years. But obviously that’s going to be different for diabetes. Reliably being able to repair pancreatic cells would be huge. If the companies selling insulin tried to internally stifle research to avoid cannibalizing their insulin business, other companies have an enormous incentive to take a crack at it.

      • Valmond@lemmy.world
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        5 months ago

        Yeah and there are other parts of the world where researchers search for stuff like this too. If it works it will being fame and money to the inventors and then the drug exists and can ve sold.

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      5 months ago

      Remember, it was the Chinese labs that also reproduced the room temperature super conductor experiment a few years ago and also found their own material…and then it all turns out to be complete bullshit.

      One patient doesn’t mean anything. It’s great if it’s real (having worked directly with China for engineering, I have zero faith this is even a real thing) but there is a lot of reason to doubt at this point.

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    5 months ago

    Mexico developed the cure many centuries ago. First you tie the person to a large log. Then smaller logs are placed around the person. Oh man I forgot what you’re supposed to do with the tinder and matches. But some research could help. It cures all sorts of stuff. Not good for burns or preexisting death from what I gathered.