Melanoma cancer vaccine with minimal side effects nearing Phase 3 in clinical trials, according to experts.

Each shot would be completely personalized to the patient.

…

Wagner’s TLPO cancer vaccine has been tested in hundreds of patients with advanced forms of melanoma in Phase 2 clinical trials.

The most recent data presented at an academic conference showed nearly 95% of people given only the vaccine were still alive three years after starting treatment and 64% were still disease-free. Among the most advanced forms of melanoma, disease-free survival after three years for people with stage III disease was 60% in the vaccine-only group, compared to about 39% in the placebo group. Disease-free survival for those with stage IV disease was about 68% in the vaccine-only group, and zero in the placebo group.

The most common side effects were redness or pain at the injection site, fever and fatigue after the injection – similar to other vaccines that stimulate an immune response.

  • MNByChoice@midwest.social
    5·
    10 months ago

    Disease-free survival for those with stage IV disease was about 68% in the vaccine-only group, and zero in the placebo group.

    The placebo group will not be getting the vaccine.

    • MxM111@kbin.social
      2·
      10 months ago

      Exactly, and I thought there are alternative treatments in case of melanoma. Not giving those is clearly unethical. Stage 4 melanoma 5 year survival rates are not that bad, and clearly more than zero with treatment.