The answer is one dll that gets loaded that causes the game to crash on startup. Go to $WINEPREFIX/drive_c/GOG Games/Cyberpunk 2077/bin/x86/ and rename GameServicesGOG.dll to GameServicesGOG.dll.bak (or delete it if you like to live life on the wild side). Now enjoy playing the update!
This was tested on Arch using AMD and latest mesa.
Yes it’s drm, and that is the debate I’ve seen around. Some are saying gog is going towards drm and some say they are already there.