§ɦṛɛɗɗịɛ ßịⱺ𝔩ⱺɠịᵴŧ

“I would rather have questions that can’t be answered than answers that can’t be questioned.” - Rich Feynman

  • 132 Posts
  • 73 Comments
Joined 3 years ago
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Cake day: March 19th, 2022

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  • You understand there’s over 13,000 cryptocurrencies, right? Your broad statement here is no different from stereotyping someone based on physical appearance. How many whitepapers, aka detailed business plans for coins, have you read? There are always scammers online, in every industry, across the board. But while there are many bullshit coins, there’s still unquestionably very solid options.

    For example, BTC has no website, no office, no owner, and is fully decentralized. Other examples of decentralized coins include ETH, XMR, ZEC, LINK, DAI, GRT, AAVE, INJ, and MKR to name a few. It’s a great practice to research and analyze data before making a statement on topics you’re unfamiliar with, but to each their own.















  • I feel like Mint is the move if you never want to utilize the terminal. But while it can be intimidating initially, after using it, you’ll grow to love it. Truly makes life way easier. I learned by first finding threads on my issues to copy and paste commands. After doing that enough you’ll gain an understanding of the main commands pretty quick. Fedora is a great starter in my mind, as you can do everything through the GUI when first starting, but unlike Mint, you can still get nerdy with the terminal when you feel up to it. Using a VM is a solid option to learn the terminal without any risk, worst case just delete the VM and make another. But you’d have to mess up pretty thoroughly to need to do that in my experience. Fedora, or Nobara which is a gaming and media centric fork of Fedora, are amazing due to the ability to run great out of the box plus being able to dial in anything you want to alter for your needs down the road. Fedora’s Software center allows you to add flatpak and snap packages, so it’ll all be in one place. Fedora 40 makes NVIDIA drivers pretty easy to deal with too. But this is just my two cents, I’m curious to see what others recommend for you.



  • Well, in digging into some research papers, I found “mast cell activation can be caused by both IgE-mediated and non–IgE-mediated triggers”.

    This is because there can be a mast cell mutation (KIT) which then doesn’t require IgE for activation. You have MMAS and not Mastocytosis, right? The mutation seems to be associated with Mastocytosis based on my understanding from the paper.

    Since mast cells aren’t privileged, they’re restricted from entering sites like the brain and spinal cord. So, if they’re in the spinal cord, you almost certainly have bigger problems than mast cell activation I’d think, as the barrier isn’t doing it’s job.

    In case you’re interested, here’s the paper on mast cell disorders: https://www.jacionline.org/article/S0091-6749(17)31025-4/fulltext

    Here’s one on the brain and spinal cord: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481533/

    The BIGGEST issue with our understanding of the immune system today is that ALL testing is done on mice. The human body on a chip technology along with the digitization of the immune system together will be a monumental step. Thankfully, it’s literally something we’ll have in the near future. Once that’s available, we’ll have human specific data plus an onslaught of constant information, which we need to help folks with all of the immune system disorders. I’m an autoimmune patient and losing my friends and family to this uncertainty has led me into the field to try and help improve our understanding. There’s legit more we don’t know than we do know about the human immune system right now.


  • While there’s no free floating IgE in your system, to degranulate mast cells need IgE bound to their surface. Thats the activation aspect. Since you need mast cells, it’s not exactly something you can turn off. Glad you know the triggers at least, gives you the opportunity to make moves accordingly!

    Here’s a great image of degranulation:

    You need two IgE’s to cross-link the same antigen as well, like what is shown above.