Bazzite! Especially if you don’t want to tinker with the system too much.
Edit: regarding security/stability; Bazzite is an unofficial member of the Fedora Immutable (erstwhile Silverblue) family. It stays in lockstep with their release cycle and the RPM OStree, so the actual “system” part is pretty much the same.
If an APU counts, pretty much everything these days. The Steam Deck, even with its now “old” APU just keeps on steaming ahead!
Caveats: HD or lower. Sometimes at 30fps for big fancy AAA games.